Role of mitochondrial dysfunction in kidney disease: Insights from the cGAS-STING signaling pathway

Role of mitochondrial dysfunction in kidney disease: Insights from the cGAS-STING signaling pathway

Blog Article

Abstract.Over the past decade, mitochondrial dysfunction has been investigated as a key contributor to acute and chronic kidney disease.However, the precise molecular mechanisms linking mitochondrial damage to kidney disease remain elusive.The recent insights into the cyclic guanosine monophosphate-adenosine monophosphate (GMP-AMP) synthetase (cGAS)-stimulator of interferon gene (STING) signaling pathway have revealed its involvement in metabo 15-gauge finish nailer cordless many renal diseases.One of these findings is that mitochondrial DNA (mtDNA) induces inflammatory responses via the cGAS-STING pathway.

Herein, we provide an overview of the mechanisms underlying mtDNA release following mitochondrial damage, focusing specifically on gymnastics wall decals the association between mtDNA release-activated cGAS-STING signaling and the development of kidney diseases.Furthermore, we summarize the latest findings of cGAS-STING signaling pathway in cell, with a particular emphasis on its downstream signaling related to kidney diseases.This review intends to enhance our understanding of the intricate relationship among the cGAS-STING pathway, kidney diseases, and mitochondrial dysfunction.